Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Taxifolin, also known as dihydroquercetin, is a flavonoid found in various plants, including Siberian larch and milk thistle. Scientific studies, mostly preclinical (animal and in vitro), suggest that taxifolin has hepatoprotective properties. Its mechanisms appear to involve antioxidant, anti-inflammatory, and anti-fibrotic effects. For example, research published in Biochimica et Biophysica Acta (2014) demonstrated that taxifolin attenuates oxidative stress and liver injury in animal models. Another study in Phytotherapy Research (2020) reported that taxifolin reduced markers of liver fibrosis and inflammation in rats exposed to hepatotoxins. In these studies, taxifolin improved liver enzyme profiles and histological features of the liver.

However, there is a lack of robust clinical trials in humans to confirm these effects. While the biochemical rationale and preclinical data are promising, evidence in human populations is limited or absent. Taxifolin is not a standard therapy for liver diseases, but it is included in some dietary supplements marketed for liver health based on its antioxidant profile. Thus, the use of taxifolin for hepatic support is primarily supported by scientific rationale and preclinical evidence, but not yet by high-quality clinical studies.

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