Evidence supporting the use of: Tauroursodeoxycholic Acid
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Tauroursodeoxycholic Acid (TUDCA) is a bile acid derivative that has been extensively studied for its effects on the hepatic (liver) system. Originally discovered as a component of bear bile used in traditional Chinese medicine, TUDCA is now synthetically produced and researched in modern medicine. Scientific evidence supports its use in liver health, particularly for its cytoprotective and anti-apoptotic properties. TUDCA has been shown to reduce endoplasmic reticulum (ER) stress and protect hepatocytes (liver cells) from damage in various models of liver disease, including cholestasis, nonalcoholic fatty liver disease (NAFLD), and liver cirrhosis. Clinical studies in humans have demonstrated that TUDCA can improve liver enzymes and histological features in certain liver conditions, especially primary biliary cholangitis. The compound is approved in some countries as a treatment for specific liver disorders. Its mechanism of action involves stabilizing cell membranes, reducing toxic bile acid accumulation, and modulating cellular stress responses. While more large-scale clinical trials are needed to clarify its efficacy in broader liver diseases, current scientific evidence largely validates TUDCA's use as a liver-supportive supplement, warranting a high evidence rating.

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