Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sulforaphane, a compound derived from cruciferous vegetables like broccoli, has been studied for its potential support of the hepatic (liver) system. The primary mechanism of action involves the activation of the Nrf2 (nuclear factor erythroid 2–related factor 2) pathway, which upregulates the expression of antioxidant and phase II detoxification enzymes in liver cells. Several animal and cell culture studies have demonstrated that sulforaphane can protect hepatocytes (liver cells) from oxidative stress and chemical-induced liver injury by boosting the body's own detoxification processes and reducing inflammation (Zhang et al., 2013). Some small human studies have noted improved biomarkers of liver function—such as reduced levels of ALT and AST enzymes—in individuals with non-alcoholic fatty liver disease (NAFLD) after supplementation with broccoli sprout extracts containing sulforaphane (Kensler et al., 2018). However, while preclinical data are robust and promising, clinical evidence remains limited in scope and size, and further research is needed to establish clear efficacy and optimal dosing in human populations. Thus, sulforaphane is scientifically justified for supporting the hepatic system, but the evidence is currently moderate rather than strong.

More about Sulforaphane
More about Hepatic System

Other ingredients that support Hepatic System

Other body systems supported by Sulforaphane

Products containing Sulforaphane