Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sesamin is a lignan compound found predominantly in sesame seeds (Sesamum indicum). There is a growing body of scientific evidence suggesting that sesamin may support liver (hepatic) health. Preclinical studies have demonstrated that sesamin possesses antioxidant properties, which are beneficial in protecting liver cells from oxidative stress and injury. In animal models, sesamin supplementation has shown hepatoprotective effects against various chemical-induced liver damages, such as those caused by ethanol and carbon tetrachloride, by modulating enzymes involved in detoxification and reducing lipid peroxidation.

Additionally, sesamin has been studied for its ability to regulate lipid metabolism in the liver. Research indicates that it can decrease hepatic fatty acid synthesis and increase fatty acid oxidation, potentially offering protective effects against fatty liver disease. Sesamin has also been observed to suppress inflammatory markers in the liver and improve overall liver function markers in animal studies. However, while these results are promising, most of the evidence comes from in vitro studies and animal models. Data from human clinical trials are limited, with only a few small studies suggesting mild beneficial effects on liver enzymes and lipid profiles. Thus, while there is a scientific basis for sesamin’s use in supporting the hepatic system, robust clinical validation in humans is still lacking.

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