Evidence supporting the use of: Schisandra chinensis
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Schisandra chinensis, also known as "five-flavor berry," has been traditionally used in Chinese medicine for liver and overall vitality support. In recent decades, its hepatoprotective (liver-protecting) effects have been investigated scientifically. Multiple preclinical and some clinical studies suggest that extracts and lignans from Schisandra chinensis can protect the liver from toxic damage, promote regeneration of liver tissue, and improve liver function markers. For example, studies have shown that schisandrin and other lignans can help reduce liver enzyme levels (such as ALT and AST) in animal models of liver injury, and have antioxidant and anti-inflammatory effects relevant to hepatic protection. Limited small human trials also indicate benefits in conditions such as hepatitis, though high-quality, large-scale randomized controlled trials are lacking. The mechanisms proposed include inhibition of lipid peroxidation, enhancement of antioxidant enzyme activity, and modulation of inflammatory pathways.

Despite gaps in rigorous human research, the convergence of traditional use and modern scientific findings provides moderate to strong support for Schisandra chinensis as a liver-supportive herb. Most safety data suggest it is well-tolerated at typical dosages, though interactions with certain medications are possible. Overall, its use for hepatic system support is justified by a combination of traditional use and a growing body of scientific evidence, warranting a rating of 4 out of 5 for evidence strength.

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