Evidence supporting the use of: Riboflavin (vitamin B2)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Riboflavin (vitamin B2) is an essential water-soluble vitamin involved in energy metabolism and redox reactions as a precursor of the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Its primary scientific connection to the hepatic system (liver) is through its role in supporting normal enzymatic processes required for liver metabolism, including detoxification and the oxidative metabolism of carbohydrates, fats, and proteins. Riboflavin deficiency can potentially result in hepatocellular dysfunction, and studies in both animals and humans have observed that chronic deficiency may contribute to liver injury, including hepatic steatosis and impaired antioxidant capacity. However, while adequate riboflavin intake is important for general liver health, there is limited evidence supporting the use of riboflavin supplementation specifically as a therapeutic intervention for liver diseases or to "support" the hepatic system in healthy individuals beyond correcting deficiency. Clinical trials directly assessing riboflavin as a treatment or preventive agent for liver disease are lacking. Therefore, the evidence for using riboflavin to support the hepatic system is largely based on its physiological necessity for hepatic metabolic functions, rather than direct clinical benefits from supplementation above recommended dietary allowances.

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