Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Riboflavin (vitamin B2) is a water-soluble vitamin that plays a crucial role in numerous metabolic processes, particularly as a component of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are essential for oxidation-reduction reactions involved in energy production and metabolism of fats, drugs, and steroids—functions that are heavily concentrated in the liver. Scientific studies indicate that riboflavin deficiency can impair hepatic function, as it is necessary for the metabolism of other B vitamins and for the detoxification processes that occur in the hepatic system. Riboflavin also plays a role in protecting the liver from oxidative stress by supporting glutathione reductase activity, which helps regenerate reduced glutathione, a vital antioxidant in the liver. While riboflavin is not widely used as a standalone treatment for liver diseases, its adequate intake is considered important for maintaining overall liver health and function. For these reasons, riboflavin is sometimes included in formulations aimed at supporting hepatic function, and its role is supported by biochemical and clinical evidence, although direct clinical trials focusing solely on riboflavin supplementation for liver disease are limited. Overall, the scientific validation is moderate, earning a mid-level evidence score.

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