Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Puerarin is an isoflavone glycoside derived from the root of Pueraria lobata (kudzu). Its use to support the hepatic (liver) system is primarily backed by preclinical scientific studies rather than traditional medicine. Experimental research, mostly in animal models and in vitro studies, has shown that puerarin possesses hepatoprotective effects. These effects are thought to be due to its antioxidant, anti-inflammatory, and anti-fibrotic properties. For example, several studies have demonstrated that puerarin can reduce liver enzyme levels, inhibit lipid peroxidation, and lessen histological liver damage induced by toxins such as alcohol, carbon tetrachloride (CCl₄), or high-fat diets.

Mechanistically, puerarin appears to modulate signaling pathways (e.g., Nrf2/ARE, NF-κB) relevant to oxidative stress and inflammation, processes known to contribute to liver injury and disease. However, human clinical data are limited, with only a few small trials or case reports suggesting benefit. Most evidence comes from laboratory or animal studies, so while the data are promising, more robust clinical trials in humans are needed to confirm efficacy and safety.

Overall, puerarin’s use for liver support is based on moderate scientific evidence, but clinical validation remains insufficient at this time.

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