Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nobiletin is a polymethoxylated flavone found predominantly in citrus peels, particularly in tangerines and oranges. Scientific studies have increasingly explored its effects on the hepatic system (liver function). Preclinical research in rodent models has demonstrated that nobiletin exhibits hepatoprotective properties. For example, studies have shown that nobiletin can reduce liver inflammation and fibrosis, as well as ameliorate non-alcoholic fatty liver disease (NAFLD) through modulation of lipid metabolism, inhibition of oxidative stress, and anti-inflammatory activity. Mechanistically, nobiletin appears to regulate signaling pathways such as AMPK and PPARα, both of which are important in liver energy homeostasis and lipid management.

That said, the bulk of evidence is derived from animal and cell-based studies, with few clinical trials in humans directly evaluating its efficacy for liver support. There is also some traditional use of citrus peels in East Asian medicine for digestive health, but nobiletin itself is not specifically cited in traditional texts for hepatic support. Therefore, while there is promising scientific evidence suggesting nobiletin’s potential benefits for the liver, human data remain limited, and definitive clinical recommendations have yet to be established.

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