Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nigella seed (Nigella sativa), also known as black seed or black cumin, has a long history of use in traditional medicine, particularly in Middle Eastern and South Asian cultures, for supporting liver (hepatic) health. In recent years, scientific studies have begun to provide support for these traditional uses. Preclinical studies (in vitro and animal research) have demonstrated that thymoquinone, the main active component of Nigella seed, exhibits hepatoprotective effects. Specifically, it has been shown to reduce liver injury caused by toxins, oxidative stress, and inflammation in animal models. For example, studies in rats have reported that Nigella sativa extracts can decrease markers of liver damage (like ALT, AST), improve antioxidant capacity, and reduce histopathological changes in the liver.

There are a limited number of small human clinical trials that suggest Nigella sativa supplementation may improve liver enzyme profiles and reduce markers of oxidative stress in individuals with non-alcoholic fatty liver disease (NAFLD) and other hepatic conditions. However, these studies are generally limited by small sample sizes and short durations. Thus, while there is promising scientific evidence, particularly from animal studies and some early human trials, larger and more rigorous clinical research is needed to confirm these benefits and establish effective dosing. Overall, the use of Nigella seed to support the hepatic system is justified primarily by a combination of traditional use and emerging scientific evidence, warranting a moderate evidence rating.

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