Evidence supporting the use of: Niacinamide (vitamin B3)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is scientifically recognized for its role in liver (hepatic) health, particularly in the context of preventing or treating niacin deficiency (pellagra), which can impact multiple organ systems, including the liver. Niacinamide is a derivative of niacin that does not cause flushing and is used as a supplement. Evidence from clinical and preclinical studies indicates that vitamin B3 is essential for hepatic function due to its role as a precursor to NAD+ and NADP+, critical cofactors in cellular metabolism and detoxification processes in the liver. Deficiency can lead to hepatic dysfunction and, in severe cases, to fatty liver or hepatic steatosis.

There is some scientific interest in the potential therapeutic effects of niacinamide for non-alcoholic fatty liver disease (NAFLD) and other metabolic liver disorders, owing to its influence on lipid metabolism and anti-inflammatory properties. However, clinical evidence for routine use in these conditions is limited and not definitive. Most established scientific support for niacinamide's role in hepatic health is related to its function in correcting deficiency states or supporting overall hepatic cellular metabolism, rather than treating specific liver diseases. Thus, while the scientific basis exists for using niacinamide to support hepatic function, especially in deficiency or increased metabolic demand, there is insufficient high-quality clinical evidence to recommend high-dose niacinamide for liver disease management.

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