Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Synopsis

L-glutathione is a tripeptide composed of glutamine, cysteine, and glycine, and is one of the most important endogenous antioxidants in the human body. It plays a critical role in hepatic (liver) health by participating in detoxification processes and protecting hepatocytes from oxidative stress and damage. The liver contains high concentrations of glutathione, which is essential for the conjugation and elimination of toxins, drugs, and metabolic waste products via the glutathione S-transferase pathway.

Numerous scientific studies have demonstrated that glutathione levels are often depleted in cases of liver disease, such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and viral hepatitis. Supplementation with glutathione or its precursors has been shown in some clinical trials and animal studies to help restore hepatic glutathione levels, reduce oxidative damage, and improve certain biomarkers of liver function. Intravenous glutathione has been used in some clinical settings for conditions like acetaminophen toxicity and chronic liver disease, although oral bioavailability is limited and remains a subject of ongoing research.

While the evidence base for oral supplementation in healthy individuals is not as robust as for specific disease states, there is considerable mechanistic and clinical support for glutathione’s role in liver health, especially under conditions of oxidative stress or toxic exposure. Therefore, the justification for using L-glutathione to support the hepatic system is primarily scientific, with a moderate to strong evidence rating.

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