Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperetin is a flavonoid found predominantly in citrus fruits and is a major metabolite of hesperidin. Scientific studies have investigated its effects on the hepatic (liver) system primarily in preclinical models. Hesperetin has demonstrated hepatoprotective properties in various animal studies, where it has been shown to attenuate liver injury induced by toxins, reduce oxidative stress, and improve biochemical markers of liver function. Its mechanisms of action are thought to involve antioxidant activity, modulation of inflammatory pathways, and improvement of lipid metabolism.

For example, research published in peer-reviewed journals has reported that hesperetin supplementation mitigated hepatic steatosis (fatty liver), reduced levels of liver enzymes such as ALT and AST (markers of liver damage), and decreased pro-inflammatory cytokine production in rodent models of nonalcoholic fatty liver disease (NAFLD) and chemically-induced liver injury. These effects are attributed to hesperetin’s ability to scavenge free radicals and regulate key signaling pathways involved in inflammation and apoptosis.

However, there is a lack of robust human clinical data directly supporting the use of hesperetin for liver health. Most evidence comes from animal and in vitro studies, and human trials are needed to confirm efficacy and safety. Therefore, while there is promising scientific evidence at the preclinical level, the overall rating reflects the current absence of large-scale or well-controlled human studies.

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