Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhetinic acid, a bioactive compound derived from licorice root (Glycyrrhiza glabra), has a long-standing history in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Ayurveda for supporting liver health. In these traditions, licorice root is often used as a harmonizer in herbal formulas and is believed to have hepatoprotective (liver-protective) properties. Historically, it has been employed to help manage liver disorders, detoxify the liver, and support overall hepatic function.

Scientifically, glycyrrhetinic acid has shown some hepatoprotective effects in preclinical studies, including anti-inflammatory and antioxidant actions that could be beneficial for liver cells. However, robust human clinical trials validating these effects for hepatic support are limited. Most evidence for its use in supporting the hepatic system remains rooted in traditional applications, rather than modern clinical validation. Additionally, safety concerns such as the potential for pseudoaldosteronism, hypertension, and hypokalemia with excessive or prolonged use also limit its widespread recommendation for liver health in evidence-based practice. Thus, while traditional use is well-established, scientific evidence is still emerging and not yet conclusive.

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