Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavonolignans, particularly those found in milk thistle (Silybum marianum), such as silybin, silychristin, and silydianin, have been extensively studied for their hepatoprotective (liver-protecting) properties. Scientific research has demonstrated that these compounds possess antioxidant, anti-inflammatory, and antifibrotic activities that are beneficial to the hepatic system. Clinical studies and meta-analyses have shown that silymarin (a mixture of flavonolignans) can improve markers of liver function, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), in patients with liver diseases including hepatitis, cirrhosis, and non-alcoholic fatty liver disease. The mechanisms proposed include stabilization of hepatocyte membranes, stimulation of protein synthesis, and enhancement of the liver’s regenerative capacity. While some clinical trials have yielded mixed results or shown modest benefits, the overall body of evidence supports the use of flavonolignans as an adjunct in the management of liver disorders. Regulatory agencies in several countries recognize milk thistle extracts as a supportive treatment for chronic liver conditions. Nevertheless, more high-quality, large-scale randomized controlled trials are needed to fully establish their efficacy and determine optimal dosing. Thus, the use of flavonolignans to support the hepatic system is justified by scientific evidence, particularly for mild to moderate liver dysfunction.

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