Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Epigallocatechin gallate (EGCG) is a major catechin found in green tea and has been studied for its potential hepatoprotective effects. Preclinical studies in animal models have shown that EGCG can reduce liver injury induced by toxins, high-fat diets, and alcohol by decreasing oxidative stress, inflammation, and lipid accumulation in the liver. Mechanistically, EGCG appears to exert its effects by scavenging free radicals, inhibiting pro-inflammatory cytokines, and modulating signaling pathways involved in liver fibrosis and apoptosis. Some human studies suggest that green tea extracts rich in EGCG may improve markers of liver health, such as reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in patients with non-alcoholic fatty liver disease (NAFLD). However, clinical data are limited, and most evidence comes from small trials or studies using green tea preparations rather than purified EGCG. Additionally, there are case reports of hepatotoxicity with high doses of EGCG supplements, indicating that while moderate consumption may be beneficial, excessive intake could be harmful. Overall, scientific evidence supports a potential role for EGCG in supporting hepatic health, but further large-scale human studies are needed to establish efficacy and safety for liver-related indications.

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