Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Epigallocatechin gallate (EGCG) is a major catechin found in green tea (Camellia sinensis). Its use to support the hepatic (liver) system has scientific backing, although most evidence comes from preclinical studies and a limited number of human trials. EGCG possesses antioxidant, anti-inflammatory, and anti-fibrotic properties, which are thought to be beneficial in protecting liver cells from damage. Animal and in vitro studies have demonstrated that EGCG can reduce oxidative stress and inhibit the progression of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and liver fibrosis by modulating cellular signaling pathways and reducing lipid accumulation in hepatocytes.

Some small-scale clinical studies have explored the effects of green tea extracts (rich in EGCG) in humans with liver disorders. These trials reported improvements in liver enzyme levels and reductions in markers of inflammation and fat accumulation. However, the overall quality of human evidence remains moderate; larger and more rigorous randomized controlled trials are needed for definitive conclusions.

It is important to note that while EGCG has potential hepatoprotective effects, high doses have been associated with rare cases of hepatotoxicity. Thus, dosage and individual susceptibility are important considerations. In summary, EGCG is scientifically investigated for liver support and shows promise, but evidence is not yet robust enough to warrant strong recommendations for clinical use.

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