Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DL-Methionine is a synthetic form of the essential amino acid methionine, which is used in both animal and human nutrition. Its use to support the hepatic system (liver health) is primarily backed by scientific evidence rather than traditional medicine. Methionine plays a critical role in methylation reactions, detoxification, and the synthesis of important molecules such as S-adenosylmethionine (SAMe), which is vital for liver function. In veterinary medicine, especially for cats and dogs, DL-Methionine is used as a dietary supplement to help manage urinary pH and can also provide hepatoprotective effects. In humans and animals, methionine deficiency can impair liver function and increase susceptibility to liver damage. Studies have shown that adequate methionine supplementation helps reduce the accumulation of fat in the liver (hepatic steatosis) and supports liver regeneration, particularly after injury or toxin exposure. However, excessive supplementation can be harmful, potentially increasing the risk of oxidative stress or liver injury in some cases. Thus, while there is a reasonable scientific basis for using DL-Methionine to support liver health, especially in cases of deficiency or increased metabolic demand, the evidence is moderate (not overwhelming), warranting a score of 3 out of 5.

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