Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Dihydromyricetin (DHM), also known as ampelopsin, is a flavonoid compound extracted from the Japanese raisin tree (Hovenia dulcis) and other sources. Its use to support the hepatic (liver) system is primarily based on preclinical scientific research. Animal studies have demonstrated that DHM possesses hepatoprotective properties, including protection against alcohol-induced liver injury, reduction of oxidative stress, and attenuation of inflammation in the liver. Several rodent studies have shown that DHM administration can decrease markers of liver damage, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and improve histological features of liver tissue exposed to toxins or alcohol. Mechanistically, DHM appears to modulate pathways related to oxidative stress and inflammation, such as the Nrf2/ARE pathway, and may enhance the metabolism and clearance of toxic substances from the liver. However, while these findings are promising, high-quality human clinical trials are limited. Most evidence for DHM's hepatic benefits comes from in vitro and animal models, with only preliminary data from small-scale human studies suggesting potential efficacy. Therefore, while DHM is used in some dietary supplements for liver support and there is a scientific rationale for its use, the current level of evidence supporting its benefit for human liver health is moderate and primarily preclinical.

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