Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihydrolipoic Acid (DHLA) is the reduced, active form of alpha-lipoic acid (ALA), an endogenous compound with antioxidant properties. ALA and DHLA have been investigated for their roles in hepatic (liver) health, primarily due to their ability to scavenge reactive oxygen species and regenerate other antioxidants such as glutathione. Some preclinical and limited clinical studies suggest that ALA and its reduced form DHLA may help protect liver cells from oxidative damage, attenuate inflammation, and improve liver function in certain conditions such as non-alcoholic fatty liver disease (NAFLD) and drug-induced hepatotoxicity. However, most of the available data relate to ALA rather than DHLA specifically, and the majority of evidence comes from in vitro studies or animal models, with relatively few high-quality, large-scale clinical trials in humans directly assessing DHLA’s effects on liver health. As a result, while the biochemical rationale for DHLA use in supporting hepatic function exists, the direct scientific validation in humans is limited. Therefore, the use of DHLA for hepatic support is backed by some scientific evidence, but overall, the clinical evidence is modest and more research is needed to firmly establish its efficacy for liver health.

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