Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cynarin is a phenolic compound found primarily in artichoke (Cynara scolymus) and is widely studied for its potential effects on the hepatic (liver) system. The use of artichoke extract, and specifically its active component cynarin, to support liver health has both traditional roots in European herbal medicine and a growing body of scientific literature. Several in vitro and in vivo studies have shown that cynarin possesses hepatoprotective effects, such as supporting bile secretion (choleretic effect) and acting as an antioxidant, which may help protect hepatocytes from oxidative stress and toxin-induced damage. Some small human clinical trials and animal studies have demonstrated improvements in markers of liver function (such as ALT and AST) and symptoms of dyspepsia with artichoke extract supplementation. However, while these results are promising, the quality, size, and consistency of clinical evidence specifically isolating cynarin’s effects (as opposed to whole artichoke extract) remain limited. Systematic reviews suggest a moderate level of evidence for artichoke extract in supporting liver health, with cynarin likely contributing to this effect. Therefore, the evidence supporting cynarin’s use for hepatic support is scientific in nature, but rated as moderate (3/5) due to the need for larger, high-quality human trials focused specifically on cynarin.

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