Evidence supporting the use of: Cholic acids (unspecified)
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Cholic acids are primary bile acids synthesized in the liver from cholesterol. They play a crucial role in the digestion and absorption of dietary fats and fat-soluble vitamins by emulsifying lipids in the intestine. The therapeutic use of cholic acid, specifically, is scientifically validated for certain rare inherited disorders of bile acid synthesis, such as bile acid synthesis defects (BASDs), where patients lack the ability to produce normal bile acids, leading to progressive liver disease. Supplementing with cholic acid can restore the bile acid pool, suppress the synthesis of hepatotoxic atypical bile acids, and improve liver function, as demonstrated in clinical studies and recognized by regulatory agencies (e.g., FDA approval for cholic acid in pediatric and adult patients with BASDs).
While cholic acid is not used broadly for general liver support in healthy individuals or for common liver diseases, its use in these specific metabolic disorders is grounded in strong scientific evidence. Guidelines and clinical trials indicate that therapy with exogenous cholic acid can prevent liver failure and improve survival in affected patients. Thus, the use of cholic acid to support the hepatic system, particularly in the context of bile acid synthesis defects, is scientifically validated and well-established, though not indicated for general liver health in the wider population.
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Other body systems supported by Cholic acids (unspecified)
Digestive SystemGall Bladder
Gastrointestinal Tract
Hepatic System
Intestinal System
Liver
Small Intestines