Evidence supporting the use of: Baicalein
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Baicalein is a flavonoid derived from the roots of Scutellaria baicalensis (Chinese skullcap), traditionally used in Chinese medicine for liver health and detoxification. Recent scientific studies have investigated baicalein’s hepatoprotective properties.
Experimental research, mostly in animal models and in vitro, indicates that baicalein exhibits antioxidant, anti-inflammatory, and anti-fibrotic effects in the liver. For instance, baicalein has been shown to reduce liver enzyme levels (ALT, AST), decrease oxidative stress markers, and inhibit inflammatory cytokines in models of chemically-induced liver injury. Some studies suggest baicalein can attenuate hepatic fibrosis by suppressing hepatic stellate cell activation and modulating TGF-β/Smad signaling pathways.
However, despite promising preclinical data, robust human clinical trials are lacking. The majority of evidence is limited to laboratory and animal models, which do not always translate directly to human benefit. In summary, there is scientific rationale and preliminary support for baicalein’s use in supporting liver function, but further high-quality human studies are needed to confirm efficacy and safety.
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