Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ampelopsin, also known as dihydromyricetin (DHM), is a flavonoid compound primarily isolated from the plant Ampelopsis grossedentata. There is a growing body of scientific research suggesting that Ampelopsin may support hepatic (liver) health. Preclinical studies in animal models have demonstrated that Ampelopsin exhibits hepatoprotective effects, such as reducing liver enzyme levels (ALT, AST), attenuating liver fibrosis, and protecting against chemically-induced liver injury. These effects are believed to be mediated through its antioxidant, anti-inflammatory, and anti-apoptotic properties. In particular, Ampelopsin has been shown to enhance the activity of endogenous antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase) and reduce oxidative stress markers in liver tissue.

Furthermore, some studies have indicated that Ampelopsin can mitigate the effects of alcohol-induced liver damage, making it of interest for the management of alcohol-related liver disorders. However, it should be noted that most of the evidence to date comes from in vitro or animal research, and robust clinical trials in humans are still lacking. While traditional use of Ampelopsis grossedentata tea exists in certain regions of China for general health and detoxification, its application specifically for liver support is primarily backed by emerging scientific, rather than longstanding ethnobotanical, evidence.

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