Evidence supporting the use of: Alpha lipoic acid
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha lipoic acid (ALA) is an antioxidant naturally present in the body and found in some foods. Its use for hepatic (liver) support has some scientific basis, particularly in the context of liver diseases associated with oxidative stress, such as non-alcoholic fatty liver disease (NAFLD) and drug-induced liver injury. Several preclinical studies and a limited number of clinical trials suggest that ALA may help protect liver cells by scavenging free radicals, regenerating other antioxidants (e.g., glutathione), and modulating inflammatory pathways. For example, some small studies in patients with NAFLD or chronic hepatitis have shown improvements in liver enzyme levels and markers of oxidative stress with ALA supplementation.

However, the evidence base is not robust: most studies are small, of short duration, or lack rigorous controls. There is stronger evidence for ALA’s use in diabetic neuropathy than for liver support. Nevertheless, its favorable safety profile and mechanistic rationale (antioxidant and anti-inflammatory effects) have led to its inclusion in some integrative protocols for liver health. It is not a standard therapy for hepatic disease, but ongoing research continues to examine its potential benefits.

In summary, while alpha lipoic acid is not a primary or universally accepted treatment for liver disorders, there is some scientific evidence—though limited—for its role in supporting hepatic health, particularly through its antioxidant actions.

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