Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin methylchalcone is a semi-synthetic derivative of hesperidin, a flavonoid found in citrus fruits. There is scientific evidence supporting its use in the treatment and support of hemorrhoids, although the strength of this evidence is moderate rather than definitive. Hesperidin methylchalcone is commonly included in phlebotropic medications, often in combination with other flavonoids such as diosmin and rutin. These compounds are believed to strengthen capillaries, reduce vascular permeability, and exhibit anti-inflammatory effects.

Several randomized controlled trials and meta-analyses have evaluated the efficacy of micronized purified flavonoid fractions (MPFF), which frequently contain hesperidin methylchalcone, in the treatment of hemorrhoidal disease. Clinical studies suggest that these preparations can reduce symptoms such as bleeding, pain, and swelling, and may accelerate symptom resolution, especially during acute attacks. The mechanism is thought to involve improvement of venous tone, lymphatic drainage, and reduction of inflammation.

However, while the overall data are consistent with a benefit, many studies use combination products, making it difficult to attribute the effect solely to hesperidin methylchalcone. Furthermore, the quality of some studies is variable, and there is a need for more high-quality, hesperidin methylchalcone-specific trials. Nevertheless, its inclusion in evidence-based guidelines (such as those from the American Society of Colon and Rectal Surgeons) supports its use as a symptomatic treatment for hemorrhoids.

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