Hesperidin methyl chalcone is a flavonoid compound derived from citrus fruits, often used in combination with other flavonoids such as diosmin. Its use in the treatment and support of hemorrhoids is primarily based on scientific evidence, especially from clinical studies conducted in Europe. Hesperidin methyl chalcone is believed to strengthen capillary walls, reduce capillary permeability, and exert anti-inflammatory effects, which can help alleviate the symptoms of hemorrhoids such as pain, swelling, and bleeding.

Several clinical trials and reviews have investigated the efficacy of hesperidin methyl chalcone, often in combination with diosmin, for the treatment of hemorrhoidal disease. These studies generally report a reduction in the duration and severity of symptoms, including bleeding and discomfort, compared to placebo. The proposed mechanism involves the improvement of venous tone and lymphatic drainage, as well as modulation of inflammatory mediators.

The evidence base is moderate (rated as 3 out of 5), as most studies are of short duration, some have methodological limitations, and hesperidin methyl chalcone is frequently studied as part of a combination therapy rather than as a sole agent. Nonetheless, major clinical guidelines in several European countries recognize micronized purified flavonoid fractions (which include hesperidin methyl chalcone) as a treatment option for hemorrhoidal symptoms.