Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonones (a subclass of flavonoids, also known as flavanones) are plant-derived polyphenolic compounds found in citrus fruits and other sources. Their use in supporting or treating hemorrhoids is primarily scientifically validated, particularly through the study of purified flavonoid fractions (often a mixture of diosmin and hesperidin) in the management of chronic venous insufficiency and hemorrhoidal disease. Multiple randomized controlled trials and meta-analyses have shown that micronized purified flavonoid fractions can help reduce symptoms such as bleeding, pain, and recurrence in patients with hemorrhoids. The proposed mechanisms include strengthening capillary resistance, reducing vascular permeability, and exerting anti-inflammatory effects.

Guidelines from several medical societies, including the American Society of Colon and Rectal Surgeons (ASCRS), mention the potential efficacy of flavonoid preparations as adjunctive therapy for symptom relief during acute hemorrhoidal episodes. However, it is important to note that much of the evidence is for specific, well-characterized flavonoid mixtures rather than for "flavonones (unspecified)" as a broad category. The overall quality of evidence is considered moderate (rated 3/5), with most studies showing benefit but some heterogeneity in outcomes and formulations.

In summary, the use of certain flavonones in hemorrhoid management is backed by scientific research, but the efficacy depends on specific preparations and dosing, and should not be generalized to all flavonones or unspecified flavonoid supplements.

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