Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bioflavonoids, particularly the mixture known as citrus bioflavonoids (often including hesperidin, diosmin, and rutin), have a long history of traditional use in the management of hemorrhoids. The rationale behind their use stems from their purported ability to strengthen capillaries, reduce vascular permeability, and exert anti-inflammatory effects. In Europe, micronized purified flavonoid fractions (MPFF)—primarily diosmin combined with hesperidin—are widely used for chronic venous insufficiency and hemorrhoidal disease, reflecting their acceptance in traditional and clinical practice. Scientific literature provides some support for their benefit, but the quality and conclusiveness of evidence vary. A few randomized controlled trials and meta-analyses suggest that flavonoid mixtures may reduce symptoms such as bleeding, pain, and recurrence rates compared to placebo, especially in acute hemorrhoidal episodes. However, most studies are modest in size, with variable quality and methodology, and often focus on specific semi-synthetic flavonoids (like MPFF) rather than generic "bioflavonoid mixtures". The mechanism is believed to involve venotonic and anti-inflammatory properties. Overall, while there is a historical and traditional basis for the use of bioflavonoids (mixtures) in hemorrhoid management, and some supportive clinical data—mainly for specific preparations—the evidence is not robust or universally accepted. Therefore, their use is best described as traditional with moderate but not strong scientific support.

More about Bioflavonoids (mixture)
More about Hemorrhoids

Other ingredients used for Hemorrhoids

Other health conditions supported by Bioflavonoids (mixture)

Products containing Bioflavonoids (mixture)