Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bioflavonoids, particularly the subgroup known as “diosmin” and “hesperidin” (often derived from citrus fruits), have been studied for their effects on hemorrhoidal disease. Scientific evidence primarily comes from randomized clinical trials and meta-analyses, which indicate that certain bioflavonoid preparations can reduce the severity and duration of symptoms such as bleeding, pain, and swelling in acute hemorrhoidal episodes. The mechanism is thought to involve strengthening capillary walls, reducing vascular permeability, and exerting anti-inflammatory effects. A 2012 Cochrane review and other systematic reviews have concluded that flavonoid mixtures (often termed “micronized purified flavonoid fraction,” containing both diosmin and hesperidin) are more effective than placebo in improving symptoms of hemorrhoids and reducing the risk of recurrence. However, the overall quality of the evidence is moderate, with some studies exhibiting methodological limitations, such as small sample sizes and heterogeneity in outcome measures. Most research focuses on specific bioflavonoid combinations rather than “bioflavonoids (unspecified),” so generalization to all bioflavonoids is limited. In summary, while there is scientific evidence—particularly for certain flavonoid preparations—supporting the use of bioflavonoids in the treatment of hemorrhoids, this evidence is not robust for all forms of bioflavonoids, and optimal dosing and formulations remain to be standardized.

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