Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B1 (thiamine) has a well-established role in cardiovascular health, particularly in cases of deficiency. Thiamine is essential for glucose metabolism, and its deficiency can lead to beriberi, which manifests in two forms: wet (affecting the cardiovascular system) and dry (affecting the nervous system). Wet beriberi is characterized by symptoms such as heart failure, edema, and cardiovascular weakness. Clinical studies and case reports have demonstrated that thiamine supplementation can improve cardiac function in individuals with thiamine deficiency, especially among populations at risk such as those with chronic alcoholism, malnutrition, or certain medical conditions like heart failure treated with long-term diuretics (which can deplete thiamine). However, evidence for benefit in heart weakness unrelated to thiamine deficiency is limited. Some small studies have explored thiamine supplementation in chronic heart failure patients, with mixed but sometimes positive results—such as modest improvements in left ventricular ejection fraction. Nevertheless, large-scale, high-quality randomized controlled trials are lacking, and current guidelines recommend thiamine supplementation primarily in cases of suspected or confirmed deficiency. In summary, there is scientific validation for using thiamine to support heart function in deficiency states, but general use for heart weakness without deficiency is not clearly supported by strong evidence.

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