Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have significant scientific support for their use in supporting cardiovascular health, including in patients with heart weakness (heart failure). Multiple large-scale clinical trials and meta-analyses have demonstrated that omega-3 supplementation can reduce the risk of cardiovascular events, lower triglyceride levels, reduce arrhythmias, and decrease overall mortality in some patient populations. The American Heart Association recommends omega-3 fatty acids for patients with coronary heart disease and for those at risk of heart failure, based on evidence that they modestly reduce the risk of sudden cardiac death and improve certain parameters of heart function. Mechanistically, omega-3s contribute to heart health by reducing inflammation, improving endothelial function, stabilizing heart cell membranes, and exerting anti-arrhythmic effects. The GISSI-Prevenzione trial and the more recent REDUCE-IT trial both showed cardiovascular benefits with omega-3 supplementation, although the magnitude of benefit varies depending on the patient population and baseline risk. While some recent studies have questioned the benefit in low-risk populations, the preponderance of evidence supports their use for secondary prevention and in patients with heart failure or weakened cardiac function. In summary, omega-3 fatty acids have robust scientific validation for supporting heart health, especially in those with existing cardiovascular disease or heart weakness, warranting a high evidence rating.

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Other health conditions supported by omega-3 fatty acids

Products containing omega-3 fatty acids

Nature's Sunshine Flax Seed Oil (With Lignans)