Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine malate is a salt composed of the amino acid l-arginine and malic acid. L-arginine is known for its role as a precursor to nitric oxide (NO), a potent vasodilator that helps regulate blood vessel tone and blood flow. Scientific interest in l-arginine supplementation for cardiovascular support stems from its potential to enhance endothelial function, improve circulation, and possibly reduce symptoms in individuals with certain types of heart weakness (such as heart failure or angina). Several small clinical studies and experimental models have shown that l-arginine supplementation can have beneficial effects on vascular function, and some evidence suggests it may modestly improve exercise tolerance and symptoms in heart failure patients. However, larger and more rigorous clinical trials have produced mixed results, and some have even reported adverse effects with l-arginine use in acute heart conditions.

Malic acid, on the other hand, is a component of the Krebs cycle, involved in cellular energy production, but its direct effects on heart function in supplement form are not well-studied. The combination as arginine malate is not specifically validated beyond the individual ingredients. While there is a plausible scientific rationale and some supporting studies for l-arginine, the overall quality and consistency of evidence are moderate at best, warranting a rating of 2 out of 5. Use of arginine malate for heart weakness should be approached with caution and under medical supervision.

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