Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Antioxidants are compounds that help neutralize free radicals, which are unstable molecules that can damage cells and tissues, including those in the cardiovascular system. Scientific interest in antioxidants and heart health has been robust for several decades, based on the observation that oxidative stress contributes to the development and progression of cardiovascular diseases, including heart failure and so-called "heart weakness" (a non-medical term often referring to reduced cardiac function).

Clinical studies have examined the effects of specific antioxidants—such as vitamin E, vitamin C, beta-carotene, and coenzyme Q10—on heart health. Some epidemiological research suggests that higher intake of antioxidant-rich foods (like fruits and vegetables) is associated with lower cardiovascular risk. However, randomized controlled trials using antioxidant supplements have produced mixed or inconclusive results. For example, large trials like the HOPE and Heart Protection Study did not show significant benefit of vitamin E or beta-carotene supplementation for preventing or treating heart disease. Coenzyme Q10, an antioxidant, has shown some promise in improving symptoms in patients with heart failure, but the evidence is not strong enough for broad recommendations.

In summary, while the biological rationale for using antioxidants to support heart health is strong and some evidence suggests potential benefit, especially from dietary sources, clinical trials of antioxidant supplements have not consistently demonstrated efficacy. Therefore, scientific support exists but is moderate and not definitive.

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