Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catalase is an antioxidant enzyme that catalyzes the decomposition of hydrogen peroxide—a reactive oxygen species—into water and oxygen. Its use in supporting or treating hearing loss is based on scientific evidence, primarily from preclinical studies. The inner ear is particularly susceptible to oxidative stress, which has been implicated in noise-induced, age-related, and ototoxic drug-induced hearing loss. Animal studies have demonstrated that catalase, either via gene therapy or pharmacological upregulation, can reduce reactive oxygen species and protect cochlear hair cells from damage caused by oxidative insults.

For example, research has shown that overexpression of catalase in the cochlea of mice can attenuate hearing loss following noise exposure. Other studies have investigated catalase-mimetic molecules or delivery systems to enhance antioxidant capacity in the inner ear. However, clinical trials in humans are lacking, and there is not yet robust evidence from human studies to firmly support the use of catalase as a treatment for hearing loss.

In summary, the use of catalase to support or treat hearing loss is grounded in scientific rationale and animal model data, but it remains experimental. More research, especially human clinical trials, is needed to determine its safety, efficacy, and practical application for hearing loss in clinical settings.

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