Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fibroblast Growth Factor (FGF) is a family of proteins involved in a variety of biological processes, including cell growth, tissue repair, and angiogenesis. In the context of hair loss or thinning, certain subtypes—most notably FGF-5 and FGF-7—have been investigated for their roles in the hair growth cycle. Scientific studies have shown that FGF-5 acts as an inhibitor of hair growth, while FGF-7 (also known as keratinocyte growth factor) promotes the proliferation of hair follicle cells and may extend the anagen (growth) phase of the hair cycle.

Preclinical research, including animal studies and in vitro experiments, has demonstrated that modulating FGF pathways can influence hair follicle activity. For example, inhibiting FGF-5 or stimulating FGF-7 has been associated with increased hair growth in animal models. Some topical products for hair loss claim to include FGF analogs or peptides that mimic their effects, based on these preclinical findings.

However, robust clinical evidence in humans is limited. Only a few small human studies or case reports exist, with mixed outcomes. No large-scale, peer-reviewed randomized controlled trials have established the efficacy or safety of FGF-based treatments for androgenetic alopecia or other forms of hair loss. As such, while the scientific rationale exists and early-stage evidence is promising, the overall level of evidence supporting the use of FGFs for hair loss remains low (rated 2 out of 5).

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