Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fibroblast Growth Factors (FGFs) are a family of proteins involved in cellular processes such as proliferation, differentiation, and survival. Their role in supporting the hair body system, particularly hair growth and regeneration, has been the subject of growing scientific interest. Several preclinical studies have demonstrated that specific FGFs, notably FGF-5 and FGF-7, play important roles in the hair growth cycle. FGF-5 has been shown to act as a suppressor of hair elongation, with inhibitors of FGF-5 prolonging the anagen (growth) phase in animal models. Conversely, FGF-7 (also known as keratinocyte growth factor) appears to stimulate the proliferation of cells in hair follicles, thus promoting hair growth. A number of topical formulations and research interventions have utilized FGFs or FGF-mimetic peptides to attempt to enhance hair regrowth or slow hair loss, particularly in the context of androgenetic alopecia. While most of the robust evidence comes from in vitro studies and animal models, there are some early-stage clinical trials suggesting potential benefits in humans, although these studies are limited in size and scope. In summary, while there is a scientific rationale and some supporting evidence for the use of FGFs in supporting hair growth, the overall evidence base remains moderate. Larger, well-controlled human studies are needed to confirm efficacy and safety before FGFs can be considered a validated therapeutic option for hair loss.

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