Stannous chloride (SnCl₂) is a compound that has been studied and used in oral care products primarily for its effects on the gums and overall oral health. The scientific evidence supporting its use is largely derived from its antimicrobial properties and its ability to reduce plaque, gingivitis, and bleeding gums. Stannous ions, when incorporated into toothpastes and mouthrinses (often as stannous fluoride, but stannous chloride is similar in mechanism), inhibit the growth of bacteria responsible for periodontal disease and help prevent the formation of dental biofilms.

Clinical trials and systematic reviews have demonstrated that toothpastes containing stannous compounds significantly reduce gingival inflammation and bleeding compared to non-stannous formulations. For example, a 2015 Cochrane review concluded that stannous fluoride toothpastes are effective in managing gingivitis, and the underlying mechanism relates to the antimicrobial and anti-inflammatory effects of stannous ions. Although stannous chloride is not as commonly used as stannous fluoride, its antimicrobial activity and ability to precipitate proteins and block dentinal tubules are similar and have been documented in scientific literature.

Overall, the use of stannous chloride in supporting gum health is justified by scientific evidence, particularly for its role in reducing gingivitis and supporting the gum tissue. However, most commercial products prefer stannous fluoride due to added benefits of fluoride for caries prevention.