Proline is a non-essential amino acid that plays a key role in the synthesis of collagen, a primary structural protein found in connective tissues, including the gums. Collagen is vital for maintaining the integrity and structure of gum tissue, suggesting a biological plausibility for proline’s role in supporting gum health. Some scientific studies have demonstrated that proline, along with other amino acids such as lysine and glycine, is required for the formation and maintenance of healthy connective tissue. Deficiencies in collagen synthesis can contribute to periodontal disease and gum degradation.

However, direct clinical trials investigating proline supplementation specifically for gum health in humans are limited. Most evidence comes from biochemical research and animal studies that elucidate the importance of proline in collagen formation. Additionally, proline is commonly found in protein-rich foods, and outright deficiencies are rare in individuals with a balanced diet. While some oral health supplements include proline based on its role in collagen production, the scientific evidence directly supporting its use for gum health is still emerging and not yet robust.

In summary, proline’s inclusion in formulations aimed at gum health is supported by basic scientific understanding of connective tissue biology, but more direct human studies are needed to confirm its effectiveness as a targeted supplement for this purpose.