Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Leucoanthocyanidins, also known as leucoanthocyanins or proanthocyanidin precursors, are a group of colorless flavonoids found in a variety of plants. Their use to support gum health primarily comes from traditional and folk medicine, particularly in cultures that have historically used plant extracts rich in polyphenols for oral care. The most common traditional link is with plant sources like grape seed, pine bark, and certain teas, which contain related compounds (proanthocyanidins), historically used for their purported astringent and anti-inflammatory properties in the mouth and gums.

Scientific evidence specifically connecting leucoanthocyanidins to gum health is currently limited. Some laboratory and animal studies on flavonoids and proanthocyanidins show potential for inhibiting oral bacteria, reducing inflammation, and strengthening connective tissue. However, these studies often use complex extracts or closely related compounds, not isolated leucoanthocyanidins. Human clinical trials directly examining the effect of leucoanthocyanidins on gum health are lacking. Thus, while there is a plausible mechanistic rationale—since polyphenols can modulate inflammation and microbial balance—direct scientific validation is insufficient at this time. The traditional use, coupled with some supportive but indirect scientific findings, warrants a modest evidence rating.

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