Evidence supporting the use of: Citrus bioflavonoids
For the body system: Gums

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids are plant-derived compounds commonly found in citrus fruits. Their use for supporting gum (periodontal) health is primarily based on their established antioxidant and anti-inflammatory properties. Several small studies and preclinical investigations have explored their effects on gum health. Bioflavonoids, such as hesperidin and rutin, have been shown to strengthen capillaries, reduce inflammation, and potentially support collagen production—important factors for maintaining healthy gum tissue. Some clinical studies suggest that supplementation with citrus bioflavonoids, often in combination with vitamin C, may help reduce gum bleeding and improve periodontal parameters in people with gum disease, possibly due to enhanced vascular integrity and reduced oxidative stress.

However, the scientific evidence is limited and not robust. Most available studies are small, short-term, or use bioflavonoids in combination with other nutrients, making it difficult to attribute benefits solely to bioflavonoids. Systematic reviews recognize a possible adjunctive role but generally call for larger, well-designed clinical trials to confirm efficacy and clarify mechanisms. Thus, while there is a scientific rationale and some supportive evidence for using citrus bioflavonoids to support gum health, the overall strength of evidence is modest (rated 2 out of 5).

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