Synopsis

Source of validity: Scientific
Rating (out of 5): 3

St. John's Wort (Hypericum perforatum) is a herbal remedy that has been used for centuries, primarily in Europe, to support mood and emotional well-being. Its use for grief and sadness is largely based on its well-documented application in mild to moderate depression. Numerous randomized controlled trials and systematic reviews have shown that St. John's Wort can be more effective than placebo and as effective as standard antidepressants (such as SSRIs and tricyclics) for mild to moderate depression, with fewer side effects in the short term. The active components, including hypericin and hyperforin, are believed to modulate neurotransmitters such as serotonin, dopamine, and norepinephrine, which play roles in mood regulation.

While grief is not identical to clinical depression, there is some overlap in symptoms such as persistent sadness, sleep disturbances, and decreased interest in daily activities. This overlap has led to the traditional and clinical use of St. John's Wort for supporting those experiencing grief or bereavement-related sadness. However, clinical trials specifically targeting grief (as opposed to depression) are lacking, so the scientific evidence for St. John's Wort’s efficacy in grief per se is indirect. Nevertheless, since grief often involves depressive symptoms, St. John’s Wort may provide some benefit for those whose grief manifests with such symptoms.

It is important to note that St. John's Wort interacts with many medications and is not suitable for everyone. Consultation with a healthcare provider is strongly recommended before use.

More about St. John's Wort
More about Grief and Sadness

Other ingredients used for Grief and Sadness

Other health conditions supported by St. John's Wort

Products containing St. John's Wort

Nature's Sunshine St. John's Wort (Concentrated)
Nature's Sunshine St. John's Wort (Concentrated Time Release)