Evidence supporting the use of: American Bugleweed
For the health condition: Grave's Disease
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
American Bugleweed (Lycopus americanus) has a history of traditional use in supporting hyperthyroid conditions such as Grave's Disease. Traditionally, both European and American species of Bugleweed have been used in folk medicine for their purported effects on the thyroid gland, particularly in cases of mild hyperthyroidism. Historical herbal texts report that Bugleweed was believed to "calm" an overactive thyroid and help relieve symptoms such as palpitations and anxiety associated with hyperthyroidism.
From a scientific standpoint, there is limited but suggestive evidence, primarily from in vitro and animal studies. Most research focuses on Lycopus europaeus (European Bugleweed), which appears to inhibit the binding of thyroid-stimulating antibodies and reduce peripheral conversion of T4 to T3. The constituents believed to be active include lithospermic acid and other phenolic compounds, which may interfere with thyroid hormone synthesis or release. However, robust clinical trials in humans, especially with Lycopus americanus, are lacking. No large, controlled studies have confirmed efficacy or safety in patients with Grave's Disease, and thus its use is not supported by modern medical guidelines.
In summary, the use of American Bugleweed for Grave's Disease is mainly justified by traditional use and limited preliminary scientific rationale, but high-quality clinical evidence is lacking. Individuals should consult a healthcare provider before using Bugleweed for thyroid conditions due to possible risks and lack of established efficacy.
