Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C has been studied for its potential role in supporting or treating gout, primarily due to its ability to lower serum uric acid levels. Gout is characterized by elevated uric acid in the blood, which can crystallize and cause joint inflammation. Several epidemiological and interventional studies have examined whether Vitamin C supplementation can help reduce uric acid levels and thus lower the risk or severity of gout attacks.

A notable randomized controlled trial published in Arthritis & Rheumatism (2005) found that a 500 mg daily dose of Vitamin C for two months modestly reduced serum uric acid levels in healthy adults. Observational studies, such as a large prospective cohort study published in Archives of Internal Medicine (2009), have shown that higher Vitamin C intake is associated with a lower risk of developing gout. The proposed mechanism is that Vitamin C increases the glomerular filtration rate and inhibits renal tubular reabsorption of uric acid, thereby promoting its excretion.

However, the effect size is generally small, and most clinical guidelines do not recommend Vitamin C as a first-line treatment for gout. Evidence is insufficient to support its use as a stand-alone therapy for acute gout or as a primary preventive strategy. Thus, while there is scientific investigation and some support, the overall quality and clinical relevance of the evidence are limited, reflected in the moderate evidence rating.

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