Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbyl palmitate is a fat-soluble form of vitamin C) has been investigated for its potential to reduce serum uric acid levels, which are elevated in gout. The scientific rationale is based on vitamin C’s uricosuric effect—it increases the excretion of uric acid in urine, potentially lowering blood uric acid levels and, theoretically, reducing gout risk or severity. Several observational studies and small clinical trials have shown that supplemental vitamin C can modestly reduce serum uric acid concentrations in healthy individuals and those with hyperuricemia. A 2008 study published in Archives of Internal Medicine showed an inverse relationship between vitamin C intake and gout incidence in men. Randomized controlled trials, however, indicate the effect is relatively small (typically a reduction of 0.5-1.0 mg/dL in uric acid), and evidence that this translates into meaningful clinical outcomes for gout patients—such as reduced flare frequency or severity—is lacking.

Ascorbyl palmitate itself is less commonly studied than ascorbic acid, but is presumed to have similar systemic vitamin C effects after conversion in the body. No major guidelines recommend vitamin C as first-line therapy for gout; it is not a replacement for standard urate-lowering medications. Thus, while there is some scientific evidence supporting a minor uric acid–lowering effect of vitamin C, the evidence for clinical benefit in treating or preventing gout is weak.

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