Evidence supporting the use of: Vitamin C (ascorbic palmitate)
For the health condition: Gout

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C, including its fat-soluble form ascorbyl palmitate, has been suggested as a potential adjunct in the management of gout based on its uricosuric effects—the ability to increase urinary excretion of uric acid. Several observational studies and a few randomized controlled trials (RCTs) have investigated the relationship between vitamin C intake and serum uric acid levels. For example, a 2005 cross-sectional NHANES study found an inverse association between vitamin C intake and serum uric acid concentrations. A 2008 RCT (Stamp et al.) showed that supplementation with 500 mg vitamin C daily led to a modest reduction in serum uric acid (about 0.5 mg/dL) in hyperuricemic subjects. However, the effect was relatively small and not sufficient as a stand-alone therapy for acute gout attacks or chronic management. Major clinical guidelines do not recommend vitamin C as a primary treatment for gout. It is also important to note that most studies use standard ascorbic acid and not ascorbyl palmitate, which is less commonly studied for this purpose. There is little evidence on the clinical effect of ascorbyl palmitate specifically in gout. Overall, while there is some scientific validation for vitamin C having a modest uric acid-lowering effect, the evidence is limited in strength and clinical significance, and it is not considered a primary or highly effective treatment for gout.

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