Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Physalis angulata, also known as cutleaf groundcherry or "ceplukan" in some cultures, has a long-standing use in traditional medicine systems for various ailments, including gout. In several regions, especially in Asia and South America, the plant’s aerial parts or fruits are employed as a folk remedy to manage symptoms associated with gout, such as joint pain and inflammation. This use is primarily based on its perceived anti-inflammatory and uric acid-lowering properties, which are key therapeutic targets in gout management. However, while there are some laboratory (in vitro and animal) studies indicating that Physalis angulata contains bioactive compounds—such as withanolides and flavonoids—with anti-inflammatory and antioxidant effects, there is a lack of robust clinical evidence or high-quality human trials specifically validating its efficacy for gout. The scientific studies available are preliminary and do not directly assess gout outcomes in humans. Therefore, the use of Physalis angulata for gout is best characterized as traditional, with a modest evidence rating, reflecting mainly anecdotal and ethnobotanical reports rather than rigorous clinical validation.

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