Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is scientifically validated for the treatment of acute gout attacks. Gout is characterized by sudden, severe episodes of pain, swelling, and inflammation in the joints, primarily due to the deposition of monosodium urate crystals. The inflammatory response is mediated by prostaglandins and other inflammatory mediators. Diclofenac, like other NSAIDs, inhibits cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and leading to decreased inflammation and pain.

Multiple clinical guidelines, including those from the American College of Rheumatology and the European League Against Rheumatism, recommend NSAIDs (including diclofenac) as first-line therapy for managing acute gout flares. Numerous randomized controlled trials and comparative studies have established the efficacy of diclofenac in rapidly reducing pain and improving function in patients experiencing acute gouty arthritis. Its effect is comparable to other NSAIDs such as indomethacin and naproxen, and it is often preferred for its tolerability and effectiveness.

Diclofenac is not used for the chronic management or prevention of gout, but its use in acute attacks is thoroughly supported by scientific evidence. However, as with all NSAIDs, potential gastrointestinal, renal, and cardiovascular side effects must be considered, especially in patients with underlying comorbidities.

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