Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Oldenlandia, particularly Oldenlandia corymbosa and Oldenlandia diffusa, has a long history of use in traditional medicine systems such as Ayurveda and Traditional Chinese Medicine (TCM). In these traditions, Oldenlandia is recognized for its purported antimicrobial, anti-inflammatory, and detoxifying properties. Specifically, it has been used for treating a variety of infectious diseases, including gonorrhea, often described in historical texts as "heat toxin" or "venereal diseases." Preparations of the plant (typically as decoctions or infusions) have been included in herbal formulas aimed at treating symptoms like urethral discharge and genital inflammation, which align with gonorrhea's clinical presentation. However, while there are in vitro studies showing Oldenlandia extracts possess some antibacterial activity, including against certain Gram-negative bacteria, there is a lack of direct scientific evidence demonstrating efficacy against Neisseria gonorrhoeae (the bacterium responsible for gonorrhea) in humans. No robust clinical trials have validated its use for this specific infection. Thus, its application for gonorrhea is primarily justified by tradition, not by current biomedical research. The evidence rating is 2, indicating traditional use with some suggestive but limited scientific support, and no definitive or clinical proof for efficacy against gonorrhea.

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