Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astaxanthin, a potent antioxidant carotenoid found in microalgae and seafood (such as salmon and shrimp), has gained attention for its potential in supporting ocular health, including glaucoma. Glaucoma is a neurodegenerative eye disease characterized by progressive optic nerve damage, often associated with elevated intraocular pressure (IOP) and oxidative stress. The scientific rationale for using astaxanthin in glaucoma centers on its antioxidative and neuroprotective properties. Several preclinical studies (in vitro and animal models) have demonstrated that astaxanthin can reduce oxidative stress in retinal ganglion cells and protect against apoptosis, which is relevant because oxidative damage is implicated in glaucoma pathogenesis.

A few small human studies and reviews suggest potential benefits of astaxanthin for general eye health, including reducing oxidative damage and inflammation. However, direct clinical evidence in patients with glaucoma is limited. There are no large randomized controlled trials specifically evaluating astaxanthin as a treatment or adjunct therapy for glaucoma. Most available data are extrapolated from its known mechanisms and effects in other ocular or neurodegenerative models. Therefore, while there is a plausible scientific basis and some preclinical support, human evidence is preliminary and insufficient to recommend astaxanthin as a primary treatment for glaucoma at this time. Its use may be considered as part of a broader antioxidant strategy for ocular health, but more robust clinical research is needed to establish efficacy and safety in glaucoma patients.

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